This interactive guide intends to accompany Carmen Benito-Vessels’ research (https://www.anle.us/publicaciones/biblioteca-digital/espana-y-la-costa-atlantica-de-los-ee.uu-cuatro-personajes-del-siglo-xvi-en-busca-de-autor/) about early modern Spain and the early modern United States (2018, 2022, and 2023). The primary goal of this project is to bring to light 16th-century colonial events that happened in the Eastern United States and shaped the history of both countries. Data, maps, and narratives include the improperly labeled "lesser navigations", which are subsequent to Juan Ponce de León’s expeditions (1510).